2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0473S12
    L-Tyrosine-17O 104931-15-9 98%
    L-Tyrosine-17O is the 17O-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-17O
  • HY-N0473S13
    L-Tyrosine-d2-2 57746-15-3 98%
    L-Tyrosine-d2-2 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-d2-2
  • HY-N0473S16
    L-Tyrosine-13C,15N 2483830-06-2 98%
    L-Tyrosine-13C,15N is the 13C and 15N labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-13C,15N
  • HY-N0830S11
    Palmitic acid-d2-1 62690-28-2 98%
    Palmitic acid-d2-1 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-d2-1
  • HY-U00001AR
    Phenglutarimid hydrochloride (Standard) 1674-96-0
    Phenglutarimid (hydrochloride) (Standard) is the analytical standard of Phenglutarimid (hydrochloride). This product is intended for research and analytical applications. Phenglutarimid hydrochloride is an anticholinergic used as an antiparkinsonian agent.
    Phenglutarimid hydrochloride (Standard)
  • HY-W001160R
    5-Hydroxyindole (Standard) 1953-54-4
    5-Hydroxyindole (Standard) is the analytical standard of 5-Hydroxyindole (HY-W001160). This product is intended for research and analytical applications. 5-Hydroxyindole is an orally active hydroxylated indole and tryptophan metabolite. 5-Hydroxyindole activates α7 nicotinic acetylcholine receptors and acts on intestinal L-type calcium channels. 5-Hydroxyindole slows down the desensitization of 5-HT3 receptor-mediated ion currents in cells. 5-Hydroxyindole causes convulsions and loss of consciousness. 5-Hydroxyindole is used in the study of neuroblastoma, schizophrenia, and diseases related to intestinal motility disorders.
    5-Hydroxyindole (Standard)
  • HY-W002112R
    (±)-Nornicotine (Standard) 5746-86-1
    (±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine (HY-W002112). This product is intended for research and analytical applications. (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia.
    (±)-Nornicotine (Standard)
  • HY-W003576R
    ACHE-IN-38 hydrochloride (Standard) 120013-39-0
    ACHE-IN-38 (hydrochloride) (Standard) is the analytical standard of ACHE-IN-38 (hydrochloride). This product is intended for research and analytical applications. ACHE-IN-38 hydrochloride (Compound 13b) inhibits the metabolic breakdown of the neurotransmitter acetylcholine (ACh) by the enzyme acetylcholinesterase (AChE) and hence alleviates memory deficits in patients with Alzheimer’s Disease by potentiating cholinergic transmission.
    ACHE-IN-38 hydrochloride (Standard)
  • HY-W004049R
    3-Hydroxybenzoic acid (Standard) 99-06-9
    3-Hydroxybenzoic acid (Standard) is the analytical standard of 3-Hydroxybenzoic acid. This product is intended for research and analytical applications. 3-Hydroxybenzoic acid is an orally active endogenous metabolite. 3-Hydroxybenzoic acid is an agonist for GPR81 and GPR109A. 3-Hydroxybenzoic acid acts as stress response desensitizers. 3-Hydroxybenzoic acid can be used for anti-inflammatory and analgesic study.
    3-Hydroxybenzoic acid (Standard)
  • HY-W004287R
    Methyl tridecanoate (Standard) 1731-88-0
    Methyl tridecanoate (Standard) is the analytical standard of Methyl tridecanoate. This product is intended for research and analytical applications. Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE).
    Methyl tridecanoate (Standard)
  • HY-W004287S
    Methyl tridecanoate-d25 1219804-90-6 98%
    Methyl tridecanoate-d25 is the deuterium labeled Methyl tridecanoate. Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE).
    Methyl tridecanoate-d25
  • HY-W007880A
    (R)-D2PM hydrochloride 172152-19-1 98%
    (R)-D2PM ((R)-Diphenylprolinol) hydrochloride is an isomer of the psychoactive substance D2PM and a pyrrolidine analog.
    (R)-D2PM hydrochloride
  • HY-W008566R
    Norharmane (Standard) 244-63-3
    Norharmane (Standard) is the analytical standard of Norharmane. This product is intended for research and analytical applications. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings.
    Norharmane (Standard)
  • HY-W008613R
    Pamoic acid (Standard) 130-85-8
    Pamoic acid (Standard) is the analytical standard of Pamoic acid. This product is intended for research and analytical applications. Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties.
    Pamoic acid (Standard)
  • HY-W009247R
    N-Desmethylolanzapine (Standard) 161696-76-0
    N-Desmethylolanzapine (Standard) is the analytical standard of N-Desmethylolanzapine. This product is intended for research and analytical applications. N-Desmethylolanzapine is an antipsychotic drug. The formation of N-Desmethylolanzapine correlates with the level and activity of human liver flavin-containing monooxygenase (FMO3). N-Desmethylolanzapine can be used in the study of antipsychotic drugs .
    N-Desmethylolanzapine (Standard)
  • HY-W009713S
    3,4,5-Trimethoxyphenylacetic acid-d2 344299-45-2 98%
    3,4,5-Trimethoxyphenylacetic acid-d2 is the deuterium labeled 3,4,5-Trimethoxyphenylacetic acid. 3,4,5-Trimethoxyphenylacetic acid is a metabolite of Mescaline.
    3,4,5-Trimethoxyphenylacetic acid-d2
  • HY-W010130R
    7-Hydroxy-3,4-dihydro-2(1H)-quinolinone (Standard) 22246-18-0
    7-Hydroxy-3,4-dihydro-2(1H)-quinolinone (Standard) is the analytical standard of 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone. This product is intended for research and analytical applications. 7-?Hydroxy-?3,?4-?dihydro-?2(1H)?-?quinolinone (3,4-Dihydro-7-hydroxy-2(1H)-quinolinone) is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B.
    7-Hydroxy-3,4-dihydro-2(1H)-quinolinone (Standard)
  • HY-W010265R
    Butyrophenone (Standard) 495-40-9
    Butyrophenone (Standard) is the analytical standard of Butyrophenone. This product is intended for research and analytical applications. Butyrophenone (1-Phenylbutan-1-one) is a dopamine receptor (DA Receptor) antagonist and can be used in research on mental disorders.
    Butyrophenone (Standard)
  • HY-W010892R
    Scopolamine hydrobromide trihydrate (Standard) 6533-68-2
    Scopolamine (hydrobromide trihydrate) (Standard) is the analytical standard of Scopolamine (hydrobromide trihydrate). This product is intended for research and analytical applications. Scopolamine hydrobromide trihydrate (Hyoscine hydrobromide trihydrate) is used in ophthalmic preparations and has the potential for transdermal patches of motion sickness.
    Scopolamine hydrobromide trihydrate (Standard)
  • HY-W011235R
    Norfluoxetine hydrochloride (Standard) 57226-68-3
    Arecoline (hydrobromide) (Standard) is the analytical standard of Arecoline (hydrobromide). This product is intended for research and analytical applications. Arecoline hydrobromide, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress.
    Norfluoxetine hydrochloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity